Lithophagia as a clue for celiac disease: a case report and literature review

Lithophagia is a type of pica that might be resulted from Iron Deficiency Anemia [IDA]which is the frequent presenting signs of Celiac Disease [CD]. A 5-year-old child with a two year history of the lithophagia with a, refractory IDA, abdominal distention and constipation. The child did not grow well and had failure to thrive. With suspicion to CD, TTg IgA level was measured and due to an incearse of TTg IgA level the patients were undergone esophagogastrodeudonoscpy and jejunal biopsy. The biopsy showed severe villous atrophy and an increase in limphoplasma cells. Biopsy confirmed diagnosis of CD and glutten free diet was initiated finally. Six months after diagnosis and commencing the gluten free diet, the lithophagia and constipation in patient eradicated completely. IDA and failure to thrive were improved and the level of TTg IgA was reached to the normal. The case demonstrated the relationship between lithophagia and CD in anemia. Therefore, in the same cases such as our case should be considered CD as the most important causes of lithophagia

Perforated meckel's diverticulum in a 3-day-old neonate; a case report

Perforation of Meckel's diverticulum is a rare complication in neonatal period. A 3-day-old term male neonate was transferred to our emergency room due to bowel perforation. Surgical exploration was done and perforated Meckel's diverticulum was detected. Pathological reportofthe tissue showed inflamed diverticulum withheterotopic gastric muco-sa. This is the first report of Meckel's diverticulum perforation inaneonate in our country

[Effects of aromatherapy by Rosaceous on the severity and systemic symptoms of primary dysmenorrhea]

Background and Aim: Dysmenorrhea, defined as pain associated with menstruation that affects millions of women in the reproductive age worldwide. Considering the high prevalence of dysmenorrhea and its adverse consequences on quality of life, the present study examined the effects of Rosaceous on the severity of primary dysmenorrhea and its systemic manifestations

Materials and Methods: This double blind clinical trial was performed on 110 students of Hamadan University of Medical Sciences. Students randomly assigned into intervention and control groups. Both groups were matched before intervention for age, education level, BMI, income, education wife, age of menarche and marital status. In the intervention group in the first 3 days of menstruation, 10 drops of Rosaceous extract were given to the subjects two times daily for two consecutive menstrual cycles. The controls take placebo. Severity of primary dysmenorrhea is compared in the two groups using the paired t test and between groups using the independent t test

Findings: The severity of primary dysmenorrhea and systemic manifestations decreased in both groups, this reduction was more significant in the Rosaceous group [p <0.001]

Conclusions: The results of this study results showed a positive impact of Rosaceous in reduction of severity of primary dysmenorrhea and systemic manifestations. It seems that can be used to reduce the severity of primary dysmenorrhea and systemic manifestations

effect of wheat germ extract on premenstrual syndrome symptoms

Pre-menstrual syndrome is one of the most common disorders in women and impairs work and social relationships. Several treatment modalities have been proposed including herbal medicines. Considering the properties of wheat germ, this study aimed to determine the effects of wheat germ extract on the symptoms of premenstrual syndrome. This triple blind clinical trial was conducted on 84 women working in hospitals affiliated to Hamadan University of Medical Sciences. Subjects completed daily symptom record form for two consecutive months. After definitive diagnosis of premenstrual syndrome, they were randomly divided into two groups of 50 people. Then, for two consecutive months, 400 mg capsules of wheat germ extract or placebo were used three times a day, from day 16 until day 5 of the next menstrual cycle. Wheat germ significantly reduced physical symptoms [63.56%], psychological symptoms [66.30%], and the general score [64.99%]. Although the severity of symptoms decreased in both groups, this reduction was more significant in the wheat germ extract group [p < 0.001]. On the other hand, physical symptoms decreased only in the wheat germ extract [p < 0.001] and there was no statistically significant difference in the placebo group. No complications were observed in any of the groups. It seems that using wheat germ extract reduces general, psychological and physical symptoms